Olmesartan medoxomil and hydrochlorothiazide are available in tablet dosage form in the ratio 20: 12.5. Two simple, accurate, precise and economic method, simultaneous equation method and multicomponent method, have been described for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide in tablet dosage form. Absorption maxima of olmesartan medoxomil and hydrochlorothiazide in distilled water were found to be 256.0 nm and 271.5 nm, respectively. Beer’s law was obeyed in the concentration range of 5-40 µg/ml for olmesartan medoxomil as well as for hydrochlorothiazide. The methods allow rapid analysis of binary pharmaceutical formulation with accuracy. Results of two methods were validated statistically and by recovery studies, and were found to be satisfactory.
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